What We Know About the Covid-Related Syndrome Affecting Children

22 mai 2020 Non Par ADMIN

For parents, one of the most reassuring aspects of the coronavirus has been that it largely spares children, only causing mild symptoms. But recent reports of a new life-threatening pediatric inflammatory syndrome are worrying many families. Children in Europe, Britain, and now the United States are being hospitalized for this mysterious illness, which can harm kids’ hearts and other organs, often requiring intensive care.

According to Gov. Andrew M. Cuomo, as of May 12, New York was investigating 102 cases of this syndrome and three deaths, and cases have been reported in 14 other states so far as well. Thankfully, this new syndrome is still quite rare and it is treatable, and most kids who develop it fully recover. Here’s what parents need to know and what they should do if they’re concerned about their children’s health.

No one knows for sure whether this new syndrome, which is now being called pediatric multisystem inflammatory syndrome, or P.M.I.S., is linked to the coronavirus, but many doctors think so. “I do think that this is related to Covid,” said Dr. Eva Cheung, M.D., a pediatric cardiologist and critical care specialist at NewYork-Presbyterian Morgan Stanley Children’s Hospital, which has treated more than 35 patients so far with the syndrome.

The vast majority of children who’ve fallen ill in New York have either tested positive for active Covid-19 infection or have had antibodies suggesting that they were exposed to the virus at some point. A few kids have tested negative for both active infection and antibodies, and it’s unclear what that means. It’s possible that these negative tests were inaccurate, Dr. Cheung said, because many coronavirus antibody tests are unreliable.

What’s interesting, though, is that most of the children who’ve gotten sick — even those whose tests indicated prior coronavirus exposure — did not report having a recent respiratory illness. This suggests that these children were either exposed to the coronavirus but didn’t get sick, or that they had very mild symptoms, said Dr. George Ofori-Amanfo, M.D., the division chief of pediatric critical care medicine at Mount Sinai Kravis Children’s Hospital.

Dr. Ofori-Amanfo suspects that children who develop this syndrome were exposed to the coronavirus, and that their bodies for some reason mounted an exaggerated — and ultimately dangerous — immune response, much like the “cytokine storms” that have caused some adults to fall quite ill in the later stages of infection.

They may “have an abnormal and aggressive immune response to Covid — and that immune response is so aggressive that it affects other organ function and affects their ability to maintain their blood pressure,” Dr. Ofori-Amanfo said. This may then cause their bodies to go into rapidly progressive shock, requiring medications and, in rare cases, the use of life support to take over the job of their heart and lungs.

Still, doctors stress that no one yet knows for sure what is going on. “We don’t even exactly know what this disease is,” said Dr. Rebecca Pellett Madan, M.D., an associate professor of pediatric infectious diseases at the N.Y.U. Grossman School of Medicine.

When it first arose, many doctors noticed that this new syndrome had features similar to Kawasaki disease, a rare condition that typically afflicts children under 5, causing their blood vessels to become inflamed. But although its symptoms are similar, and both are conditions marked by widespread inflammation, most doctors do not think this current syndrome is the same thing as Kawasaki. “They may share features,” Dr. Cheung said, but “I truly do think that this is its own syndrome.”

The pediatric inflammatory syndrome also looks a lot like toxic shock syndrome, which occurs when the body goes into shock because it has been exposed to toxins released during bacterial infections. But Dr. Ofori-Amanfo said that none of Mount Sinai’s patients had evidence of a bacterial infection in their body, so it was likely that the pediatric inflammatory syndrome, again, looked similar to toxic shock syndrome but was not actually the same thing.

The good news is the new pediatric inflammatory syndrome is easy to spot — its symptoms are serious enough that parents should be able to notice them. All patients developed a fever of 101 or higher that didn’t go away, said Dr. James Schneider, M.D., a pediatric critical care specialist at Cohen Children’s Medical Center in Queens, which has treated more than 40 patients so far with the syndrome. Dr. Cheung agreed, adding that kids with temperatures of 99 or 100 probably aren’t at risk. “That is not what we’ve seen here. The patients that we’ve seen that have needed admission to the hospital have had pretty moderate to high fevers,” she said.

Most kids also develop serious abdominal pain that get progressively worse over time. It’s not a garden-variety kids’ stomach ache; it’s serious pain that is often accompanied by vomiting and diarrhea and is “severe enough for the parent to be worried,” said Dr. Ofori-Amanfo. For some kids, the pain has been so bad that parents and doctors assumed the child had appendicitis and needed surgery, said Dr. Nadine Choueiter, M.D., a pediatric cardiologist at the Children’s Hospital at Montefiore in the Bronx.

Many kids with the syndrome — but not all — develop rashes, too. The rashes are red and often appear on the hands, forearms and chest, Dr. Ofori-Amanfo said, although they can appear anywhere. They typically turn white when you press on them, and then turn red again when you stop. They also usually cover a large area — a child’s entire face, for instance, or a substantial part of their arms or legs. “It’s not like a tiny speck of a rash. It’s pretty diffuse,” Dr. Cheung said.

Kids with the syndrome sometimes also have red eyes, cracked lips, a sore tongue, swollen hands and feet and they might complain of muscle soreness and not want to walk. But these symptoms are not as common as the fever and abdominal pain, doctors said, and some of the symptoms may come and go. “Sometimes the skin and the eye findings kind of wax and wane to the point that one doctor will go in the room and say ‘I saw a rash,’ and then another doctor goes in the room three hours later and the rash is entirely different,” Dr. Choueiter said.

“All our patients have been previously healthy patients, with no underlying illnesses,” Dr. Ofori-Amanfo said. Some of the kids who developed the syndrome even had multiple siblings who remained perfectly healthy.

  • Frequently Asked Questions and Advice

    Updated May 20, 2020

    • How many people have lost their jobs due to coronavirus in the U.S.?

      Over 38 million people have filed for unemployment since March. One in five who were working in February reported losing a job or being furloughed in March or the beginning of April, data from a Federal Reserve survey released on May 14 showed, and that pain was highly concentrated among low earners. Fully 39 percent of former workers living in a household earning $40,000 or less lost work, compared with 13 percent in those making more than $100,000, a Fed official said.

    • What are the symptoms of coronavirus?

      Common symptoms include fever, a dry cough, fatigue and difficulty breathing or shortness of breath. Some of these symptoms overlap with those of the flu, making detection difficult, but runny noses and stuffy sinuses are less common. The C.D.C. has also added chills, muscle pain, sore throat, headache and a new loss of the sense of taste or smell as symptoms to look out for. Most people fall ill five to seven days after exposure, but symptoms may appear in as few as two days or as many as 14 days.

    • How can I protect myself while flying?

      If air travel is unavoidable, there are some steps you can take to protect yourself. Most important: Wash your hands often, and stop touching your face. If possible, choose a window seat. A study from Emory University found that during flu season, the safest place to sit on a plane is by a window, as people sitting in window seats had less contact with potentially sick people. Disinfect hard surfaces. When you get to your seat and your hands are clean, use disinfecting wipes to clean the hard surfaces at your seat like the head and arm rest, the seatbelt buckle, the remote, screen, seat back pocket and the tray table. If the seat is hard and nonporous or leather or pleather, you can wipe that down, too. (Using wipes on upholstered seats could lead to a wet seat and spreading of germs rather than killing them.)

    • Is ‘Covid toe’ a symptom of the disease?

      There is an uptick in people reporting symptoms of chilblains, which are painful red or purple lesions that typically appear in the winter on fingers or toes. The lesions are emerging as yet another symptom of infection with the new coronavirus. Chilblains are caused by inflammation in small blood vessels in reaction to cold or damp conditions, but they are usually common in the coldest winter months. Federal health officials do not include toe lesions in the list of coronavirus symptoms, but some dermatologists are pushing for a change, saying so-called Covid toe should be sufficient grounds for testing.

    • Should I wear a mask?

      The C.D.C. has recommended that all Americans wear cloth masks if they go out in public. This is a shift in federal guidance reflecting new concerns that the coronavirus is being spread by infected people who have no symptoms. Until now, the C.D.C., like the W.H.O., has advised that ordinary people don’t need to wear masks unless they are sick and coughing. Part of the reason was to preserve medical-grade masks for health care workers who desperately need them at a time when they are in continuously short supply. Masks don’t replace hand washing and social distancing.

    • What should I do if I feel sick?

      If you’ve been exposed to the coronavirus or think you have, and have a fever or symptoms like a cough or difficulty breathing, call a doctor. They should give you advice on whether you should be tested, how to get tested, and how to seek medical treatment without potentially infecting or exposing others.

    • How can I help?

      Charity Navigator, which evaluates charities using a numbers-based system, has a running list of nonprofits working in communities affected by the outbreak. You can give blood through the American Red Cross, and World Central Kitchen has stepped in to distribute meals in major cities.


Doctors are also seeing the syndrome in both sexes, but “we are seeing it in slightly more boys than girls — like 60 percent boys, 40 percent girls,” Dr. Choueiter said. The age range is wide, too; the Children’s Hospital at Montefiore has seen the syndrome in kids from 5 months to 20-years-old. It has not been observed in adults.

The one thing that clearly puts children at risk is living in an area with a lot of Covid-19 cases. But again, because kids who get sick with the syndrome didn’t necessarily have any Covid-19 symptoms, it can be hard for parents to know if their children might be at risk.

If you child has a persistent fever above 101 — and especially if they develop other symptoms consistent with the syndrome, like a bad stomach ache — contact your pediatrician. “Ask to speak to them over the phone or do a telemedicine visit and have your pediatrician walk through the steps of what to look for,” Dr. Pellett Madan suggested. Dr. Cheung agreed, noting that in geographical areas where this syndrome has appeared, hospitals are making sure that local pediatricians know what to look for and what to do.

If your child has a fever but is in good spirits and is eating and drinking and not complaining about pain, you don’t need to rush them to the emergency room, but again, stay in touch with your doctor. On the other hand, if your child really seems unwell — isn’t eating or drinking, doesn’t want to move much and especially if they develop a rash or red eyes along with a high fever — it’s not a bad idea to go directly to the E.R., Dr. Pellett Madan said.

It’s estimated that hundreds of thousands of children around the country have contracted the coronavirus, and the vast majority only have very mild symptoms. This serious syndrome is “still a very rare occurrence,” Dr. Schneider said. Your child is probably going to be fine.

Even the few kids who do go on to develop this inflammatory syndrome usually get better. “Some of them don’t even go to the intensive care unit. They’re with us for a few days, less than a week and they go home,” Dr. Choueiter said. They’re typically treated with what’s called “supportive care” to ease their symptoms: They might get fever reducers to lower their temperature, IV fluids to keep them hydrated, medications to increase blood pressure if it drops, and steroids or other drugs to quell the inflammation. Ultimately, “most of these children do fine,” Dr. Choueiter said.

Melinda Wenner Moyer is a mother of two and a science journalist who writes for Slate, Mother Jones, Scientific American and O, The Oprah Magazine, among other publications.


Source